Careful driving toward and away from Vedauwoo/ BS traffic stops

David Sahalie wrote:Great news Joan Pro! Cannabis can be used to treat shizophrenia healthland.time.com/2012/05…

Early evidence suggests that CDB's, one of the active but non-psychedelic components in MJ may indeed be quite effective at that. But a concordance of studies has shown that MJ, in and of itself, can make schizophrenia worse. This is reported in your link.
This sounds like a technicality, but it would sure suck to have people with a common medical problem thinking about self-medicating in the wrong way because they heard something that was not quite true and didn't look into the details.
Having dealt with mentally ill patients who took psychedelics, I assure you this is not completely preposterous. It is also established fact that some hallucinogenics can trigger the onset of dormant schizophrenia, though the mode of action is not clearly understood, and I can not tell you if MJ is on the list. I'm just saying that people with Sz (or a family history of Sz, the most heritable psychiatric condition of all) should avoid whole MJ, even if seeking CBD to treat their condition.

And thanks for the link, BTW. Seriously. It was a good read.

FYI: (as a curiosity for those who are) Did you know that Nicotine has been certainly proven as a protective and perhaps mitigating drug Vs Schizophrenia?

I'm curious as to what color your plates are on your vehicle TBlom.
Since Colorado has many different colored license plates to choose from, I wonder if there is a bias against the traditional green plates v.s. the plethora of other styles?

Tom plater what wyomings refer to as the "greenie " plate is often singled out , The green plate is a symbol for marijuana use and Colo Radens are often referred to as greenies another term for soft or new.

Tony B wrote: But a concordance of studies has shown that MJ, in and of itself, can make schizophrenia worse. This is reported in your link. This sounds like a technicality, but it would sure suck to have people with a common medical problem thinking about self-medicating in the wrong way because they heard something that was not quite true and didn't look into the details. Having dealt with mentally ill patients who took psychedelics, I assure you this is not completely preposterous. It is also established fact that some hallucinogenics can trigger the onset of dormant schizophrenia, though the mode of action is not clearly understood, and I can not tell you if MJ is on the list. ?

Most of those studies were paid for by pharmaceutical companies, who's results, as we all know, are always unbiased! And yes, MJ is on that list.

While doing research on this same subject in grad school I looked at a plethora of studies covering this same correlation between schizophrenia and various cannabinoids. One study done in NZ in the 1990's was especially compelling. The problem with this study and every other that I researched was that the correlation did not really prove causation, even in longitudinal studies with a huge samplings. So, it is not a fact, but because the high level of correlation and the ramifications of that correlation, the medical community began to accept this supposition as fact to avoid the potential consequences.

Because "the mode of action" is not understood, it's an insinuation that the correlation is in fact proving causation. Until this new information came out, there was no reason for professionals to question the acceptance of correlation proving causation, especially with the DEA breathing down their necks. But now with this new evidence, perhaps we will finally get a study that can answer this question more concretely.

Any psychotic teenage twins wanna get high?

No, they're referred to as greenies because they've had green plates as the standard since 1958. More or less as long as climbers have been coming from Colorado to climb in Wyoming, they've had green plates. As there's always been an undercurrent of xenophobia in the Wyoming citizenry, they naturally came up with derisive nicknames pretty early on. There's no additional implications re: marijauna, or relative freshness (vis greenhorns).

J Q wrote: Most of those studies were paid for by pharmaceutical companies, who's results, as we all know, are always unbiased! And yes, MJ is on that list. While doing research on this same subject in grad school I looked at a plethora of studies covering this same correlation between schizophrenia and various cannabinoids. One study done in NZ in the 1990's was especially compelling. The problem with this study and every other that I researched was that the correlation did not really prove causation, even in longitudinal studies with a huge samplings. So, it is not a fact, but because the high level of correlation and the ramifications of that correlation, the medical community began to accept this supposition as fact to avoid the potential consequences. Because "the mode of action" is not understood, it's an insinuation that the correlation is in fact proving causation. Until this new information came out, there was no reason for professionals to question the acceptance of correlation proving causation, especially with the DEA breathing down their necks. But now with this new evidence, perhaps we will finally get a study that can answer this question more concretely.

You are right, in the 1990's less was understood. Took classes back then too. Sounds like you are missing out on 20 years worth of data. Lets face it - we were dealing with what is now obsolete technology back then.

But the most recent course I took (just this year) was much more clear on that Vs psychedelics in general.
Mapping of the genome and the identification of the markers for schizophernia have simplified analysis quite a bit. It is presently understood that the largely genetic (8P21 area, more or less surrounding the Neuregulin-1 gene), but partially penetrant condition (48% in identical twins) can be triggered by various psychadelics... the more powerful (IE LSD) the worse the odds, it seems. But as I said before, I can't say about the data on THC itself and how significant the risk is.
However, the evidence for even LSD does not seem not suggest that it poses a measurable additional risk to those who are not predisposed to the condition. (Won't make you crazy unless you already are) I believe that this includes heterozygote conditions, but I'd have to look that up in my books/notes if you are interested/care what present knowledge is.
You are also correct that a lack of good, solid animal models and the severe consequence of the human condition prevents solid lab work on a per-subject basis. Wish it was a little better understood. But I wouldn't jump to blame in on "big pharma".
There's an awful lot of research going on by people who have it in the family and are NOT in it for the money.